The main differences between an e-bike and an electric scooter are their design, wheel size, power, and riding experience. E-bikes are similar to regular bicycles but have a battery-powered motor, so they provide pedaling assistance, whereas electric scooters have a platform for standing on and are driven using handlebars. E-bikes typically have larger wheels, offer more power, and provide a longer range due to their larger batteries compared to electric scooters.